CD8A and neoplasm: The activation of anti-tumor CD8+ T-cell responses is fulfilled through a process known as cross-priming and requires the uptake of extracellular Ag also in the form of tumor cells by the antigen-presenting cell (APC), which subsequently delivers the engulfed material to a distinct endosomal/lysosomal pathway that allows the processed peptides to be presented on MHC class-I (MHC-I) molecules (cross-presentation) (1).