CD8A and neoplasm: In vitro or in vivo exposure of CD8α DC that have engulfed irradiated tumor cells to IFN-I resulted in three distinct effects: (i) increased retention of engulfed apoptotic material that correlated with decreased endosomal acidification and resulted in enhanced Ag cross-presentation, (ii) prolonged survival of phagocytic CD8α DC, and (iii) phenotypic activation of the cross-presenting DC that resulted in DC “licensing” for cross-priming (10).