CHI3L1 and neoplasm: Faibish et al. (2011) found that neutralizing antibody to YKL-40 blocks tumor angiogenesis by inhibiting endothelial cell tube formation (Faibish et al., 2011) while (Kawada et al., 2012) demonstrated increased microvessel density in CHI3L1-transfected colon cancer cells (Kawada et al., 2012).