Taking the generalized view that couples endothelial dysfunction with insulin resistance (Kim et al., 2006) and considering insulin-mediated capillary recruitment as a rate-limiting step for glucose uptake (Rattigan et al., 1999; Chiu et al., 2008), the fact remains that the targeted disruption of the insulin receptor in the endothelium does not alter glucose homeostasis (Vicent et al., 2003; Duncan et al., 2008; Rask-Madsen et al., 2010). The gene discussed is INSR; the disease is Insulin resistance.