SLC4A7 and Hypertension: The importance of NBCn1 for blood pressure regulation was for instance proposed by a recent genome-wide association study linking the rs13082711 SNP located 10 kb 5′ of the coding region of SLC4A7 to hypertension (Ehret et al., 2011), and this finding was concurrently reinforced by an experimental study showing that NBCn1 knockout mice have a complex blood pressure phenotype and an altered vascular function (Boedtkjer et al., 2011), see section The Resistance Arteries and Microvasculature.