Neuroinflammation is evident in rodent models of inherited ALS overexpressing mutant Cu/Zn superoxide dismutase (SOD1) and in ALS human patients (Gurney et al., 1994; Bruijn et al., 1997; Howland et al., 2002; McGeer and McGeer, 2002; Appel, 2009). Here, SOD1 is linked to amyotrophic lateral sclerosis.