In order to analyze whether mice deficient in immunoproteasome subunits are susceptible to experimental autoimmune encephalomyelitis, LMP2−/−, LMP7−/−, MECL-1−/−, and C57BL/6 control mice were immunized with MOG35–55 peptide. The gene discussed is PSMB8; the disease is experimental autoimmune encephalomyelitis.