ARC has been reliably associated with both LTP38 and LTD39 with ARC mRNA being transported to active synaptic regions via the dendritic spine where it is then translated and serves to modulate AMPA trafficking.40De novo mutations in the ARC protein have been implicated in schizophrenia,20 a disease in part predicted by a low premorbid cognitive ability,41 which may be due to a shared genetic component between the two traits.42 Here, ARC is linked to schizophrenia.