More interestingly, Zhou et al. [19] reported that miR-340 may inhibit osteosarcoma tumor growth and metastasis by directly targeting ROCK1, which is a GTP-dependent serine/threonine protein kinase interacting with the Rho G-protein through its Rho-binding domain, thereby mediating Rho signaling [20,21]. Here, RHO is linked to osteosarcoma.