Especially regarding ROCK1, Vigil et al. [24] demonstrated that ROCK1 was required for non-small cell lung cancer anchorage-independent growth and invasion, Wu et al. [25] found that the positive expression rates of ROCK1 expression in normal tissue, dysplasia and gastric carcinoma showed an increasing trend and were correlated with tumor lymph node metastasis and TNM stage, Majid et al. [26] showed that oncogene ROCK1 may act as a direct target of tumor suppressor miR-1280 in bladder cancer. This evidence concerns the gene ROCK1 and neoplasm.