For instance, a genome-wide analysis in yeast [83], chicken [84], and several prostate cancer cell lines [68] demonstrated that histone H2A.Z acetylation is found at promoters of actively transcribing genes and nonacetylated H2A.Z is present at poised promoters of genes that are not actively undergoing transcription. The gene discussed is H2AZ1; the disease is prostate carcinoma.