As shown in Figure 1, mouse Ly6C+ monocytes have a high antimicrobial capability due to their potent capacity for phagocytosis, secrete ROS, TNFα, nitric oxide, IL-1β, little IL-10 upon bacterial infection[17] and large amount of type 1 interferon (IFN) in response to viral ligands[18]. The gene discussed is IL10; the disease is bacterial infectious disease.