MTOR and leiomyosarcoma: All in all, PTSMT show more histological features of benign leiomyomas rather than leiomyosarcomas [1,2] and our group has previously analysed cell cycle factors, cytokines and gene promoter methylation in PTSMT and found an activated phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) cell cycle pathway as well as expression of vascular endothelial growth factor (VEGF) and Fms-related tyrosine kinase 1 (FLT1/VEGFR1) [1].