The frequency of IL28B CC in HCV1 patients was lower than in healthy controls, this fact may mean that individuals with IL28B CC genotype are protected against chronic hepatitis C. Patients with IL28 CC genotype may have a high likelihood of SVR and possibly need only the standard of care P/R treatment, particularly if they have other positive predictors: low viral load, young age, female, short duration of infection, absence of cirrhosis and low BMI. Here, IFNL3 is linked to Cirrhosis.