Microarray studies found that the expression of the mRNA for the transferrin receptor is up-regulated in normal-appearing white matter in MS patients (Graumann et al., 2003), in periplaque white matter, and possibly in active lesions (Hametner et al., 2013), but these studies were focused on gene expression and did not study transferrin protein expression. The gene discussed is TF; the disease is myeloid sarcoma.