Although hemopexin binds and helps remove free heme, it is possible that hemopexin-deficient oligodendrocytes in the knockout mice were more sensitive to inflammation and/or allowed for a greater response by Th17 cells (Rolla et al., 2013), which promote pathology in EAE and MS (Jadidi-Niaragh and Mirshafiey, 2011). The gene discussed is HPX; the disease is myeloid sarcoma.