Regarding the above, also that iron has been implicated in abnormal insulin secretion in patients with BTM or hemochromatosis [44, 78] and that OS might be responsible for a decline in insulin-mediated glucose uptake in BTM patients, leading to insulin resistance [79], we consider that the evaluation of AGEs, as markers of OS, in relation to iron overload, insulin resistance, and ovulation potential would be of great value. The gene discussed is INS; the disease is Insulin resistance.