Regarding the above, also that iron has been implicated in abnormal insulin secretion in patients with BTM or hemochromatosis [44, 78] and that OS might be responsible for a decline in insulin-mediated glucose uptake in BTM patients, leading to insulin resistance [79], we consider that the evaluation of AGEs, as markers of OS, in relation to iron overload, insulin resistance, and ovulation potential would be of great value. This evidence concerns the gene INS and Tangier disease.