PTGS2 and colorectal carcinoma: Numerous genetic alterations, including polymorphisms in the cyclooxygenase (COX)-2 and 5-lipoxygenase (LOX) genes, have been associated with an increased risk of CRC and a poor prognosis, as well as a high fat intake, which increases the risk of developing tumors due to arachidonic acid metabolism that produces proinflammatory substances (6).