The inflammation-related cytokines, interleukin (IL)-6, IL-12, tumor necrosis factor (TNF)-α and interferon (IFN)-γ, were used to analyze these preventative effects on azoxymethane (AOM)- and dextran sulfate sodium (DSS)-induced colon carcinogenesis in mice. The gene discussed is TNF; the disease is digestive system neoplasm.