The inhibition of the Notch1 pathway has been shown to allow glioblastoma cells to overcome apoptosis resistance and become sensitized to apoptosis that is induced by ionizing radiation, the death ligand tumor necrosis factor-related apoptosis-inducing ligand or the Bcl-2/Bcl-XL inhibitor ABT-737 (26). The gene discussed is BCL2; the disease is glioblastoma.