NOTCH1 and neoplasm: Among the 11 factors that were analyzed (age, gender, tumor location, tumor size, tumor differentiation, depth of tumor invasion, vascular invasion, lymph node and distant metastasis, and NICD and p21 protein expression; Table IV), the univariate analysis showed that tumor differentiation, depth of tumor invasion, vascular invasion, lymph node metastasis, and NICD+ and p21+ protein expression were eligible for the multivariate analysis (Table V).