Moreover, the observations were also found to correlate with a previous study by Matsunaga et al, who suggested that the interaction between α4β1 expressed on leukemic blasts and FN on stromal cells activate PI3K/Akt/Bcl-2 signaling, an important determinant of AML chemosensitivity and the level of MRD in AML patients (22). Here, BCL2 is linked to acute myeloid leukemia.