A few pharmacological studies have shown that ketamine, desipramine and oxytocin, which are known to ameliorate both depression and pain [233-236], were effective in reversing depressive-like behaviors (forced swimming test) in rats with neuropathy, and that the effects were seen at lower doses that those needed for alleviation in sensory hypersensitivity [218,237,238]. This evidence concerns the gene OXT and neuropathy.