SOD1 and amyotrophic lateral sclerosis: Further evidence of cell-autonomous toxicity in C. elegans has been obtained by co-expressing tissue-specific temperature-sensitive (ts) mutant proteins with polyglutamine (polyQ; associated with trinucleotide-repeat disorders) and superoxide dismutase 1 [SOD1; associated with amyotrophic lateral sclerosis (ALS)] (Gidalevitz et al., 2006; Gidalevitz et al., 2009).