HSPA5 and gastric cancer: The eIF2 is regulated by a mechanism involving both guanine nucleotide exchange and phosphorylation at the α-subunit, which is a target for a number of serine kinases that phosphorylate serine 51 (Lee et al. 2008; Teske et al. 2011).Our data showed that AM2 treatment was able to upregulate BiP expression in dose-dependent manner in gastric cancer cells.