CASP9 and gastric cancer: The results of our study showed that the ethanolic extract of ufUJ caused a loss of plasma membrane integrity and induced ER stress and apoptosis in human gastric cancer cells through the upregulation of BiP and activation of caspase-9, caspase-6, and caspase-3, which play an important role in the apoptotic process (Fig. 4, 5).