Of the out-of-frame validated chimeras, we identified recurrent expressed chimeric transcripts involving CDK12 (2.7%) and RAE1 (1%), and DNA rearrangements involving C17ORF57 (0.5%), NSF (0.5%), USH2A (0.5%), and LASP1 (1%) from unselected breast cancers in external datasets 12,15–17,41–43 (Supplementary Table 7). The gene discussed is CDK12; the disease is breast cancer.