Although HCMV infection stimulates expression of TRAIL receptor 2 (TR2) in fibroblasts, gpUL141 binds TR2 directly to sequester the DR in the endoplasmic reticulum, thereby protecting HCMV-infected cells against both soluble TRAIL and TRAIL-dependent NK cell-mediated killing (Nemčovičová et al., 2013; Smith et al., 2013). Here, TNFSF10 is linked to cytomegalovirus infection.