PIK3CA and colorectal carcinoma: Moreover both mTORC1 and mTORC2 complexes were shown to regulate epithelial-mesenchymal transition (EMT), motility, and metastasis of CRCs via RhoA and Rac1 GTPases, providing the rationale for including ATP-competitive mTOR-selective or PI3K/mTOR dual inhibitors for therapy of CRC patients [161].