MTOR and colorectal carcinoma: Although mutations in Akt genes are rarely found in CRC [14], a somatic missense mutation of Akt1 (E17K) in the pleckstrin homology (PH) domain resulting in constitutive association of Akt1 with the plasma membrane and Akt1 prolonged activation has been reported in CRC, which can lead to mTOR deregulation [15].