IGFBP3 and colorectal carcinoma: The methylation status of 12 CIMP markers, namely, ADAMTS1, CHFR, IGF2, IGFBP3, NEUROG1, SFRP1, WRN, CRABP1, MGMT, RASSF1A, RUNX3, and SFRP2 was also frequently higher in CRC tissues compared with adjacent normal tissues (Figure 2A).