The methylation status of 12 CIMP markers, namely, ADAMTS1, CHFR, IGF2, IGFBP3, NEUROG1, SFRP1, WRN, CRABP1, MGMT, RASSF1A, RUNX3, and SFRP2 was also frequently higher in CRC tissues compared with adjacent normal tissues (Figure 2A). This evidence concerns the gene CHFR and colorectal carcinoma.