TXN and breast carcinoma: The false negative patients within the box (region b in Figure 5B) determined by the cut-off value of CA15-3 (29.8227 U/mL) are rescued from the wrong diagnosis by diagnosing breast cancer with the cut-off value of Trx1 (32.1725 ng/mL), due to the higher sensitivity of Trx1 (89.8%) compared to CA15-3 (48.6%).