TXN and breast carcinoma: The false negative group within the box (region b in Figure 5A) determined by the cut-off value of CEA (8.28 ng/ml) are rescued from wrong diagnosis by diagnosing breast cancer with the cut-off value of Trx1 (32.17 ng/ml), which is due to the superior sensitivity of Trx1 (89.8%) compared to that of CEA (54.4%).