Analysis of serum Trx1 level in normal female and patients with breast cancer as function of age revels that the level in female control seems to increase as a function of age (P = 0.0848) (Figure 1B) indicating a weaker association with the age, but the patient level does not response to increase of age (P = 0.3605) (Figure 6A). Here, TXN is linked to breast carcinoma.