In summary, considering the sensitivities derived from each of three sets of combinational analyses, the set of Trx1 and CA15-3 is the most efficient combination for the detection of the patients with breast cancer among three sets of combination (a sensitivity of 97.0% for a set of Trx1 and CA15-3, 91.9% for a set of Trx1 and CEA, and 80.7% for set of CEA and CA15-3). Here, TXN is linked to breast cancer.