Taking into account that the Fas apoptotic pathway has been implicated in type 2 diabetes and that a high glucose intake can induce vascular endothelial cell apoptosis and higher risk of myocardial infarction [33,34], we hypothesized that the association between the FAIM2-rs7138803 polymorphism and heart rate and cardiovascular disease would be greater in type 2 diabetic subjects. Here, FAS is linked to cardiovascular disorder.