Demonstrated to be up-regulated in cancer biopsies [24], ZNF300 binds the sequence C(t/a)GGGGG(g/c)G, found in the promoter regions of genes including IL-2, IL-2Rb, CD44, p53, TNF-a, and TRAF2, which play crucial roles in various tumorigenic and inflammatory processes. The gene discussed is CD44; the disease is cancer.