Until now, alginates have been used for oral administration in preclinical models to encapsulate antitubercular drugs [43], hepatitis B antigen [47], pDNA coding for fish lymphocystis disease virus (LCDV) [48], insulin [49], the anti-inflammatory tripeptide Lys-Pro-Val (KPV) to treat inflammatory bowel disease (IBD) [50], oral DNA vaccine against infectious pancreatic necrosis virus [51], and antisense DNA oligonucleotides [46]. This evidence concerns the gene INS and inflammatory bowel disease.