MAPK8 and neoplasm: Curiously, JNK induced secretion of JAK-STAT inducing cytokines (Upd-1, -2, -3) by the dying midgut cells is known to be a key mediator of tissue regeneration (Jiang et al., 2009), reminiscent of the positive feedback loop created between TAHs and tumor cells in the imaginal disc tumor models discussed above (Pastor-Pareja et al., 2008).