TNFSF10 and periodontitis: Together, these results support the contention that the induced expression of death receptors renders these cells sensitive to the apoptotic actions of TRAIL, and provide a potential mechanism underlying the reported increase in TRAIL sensitivity of human alveolar osteoblasts isolated from patients with periodontitis (Mori et al., 2009) and transformed osteoblasts (Atkins et al., 2002).