Overexpression of syndecan-1 resulted in a downregulation of syndecan-2 and upregulation of syndecan-4 in epithelioid mesothelioma cells (90, 99), whereas in epithelioid fibrosarcoma cell line syndecan-2 was upregulated (92), and in a sarcomatoid fibrosarcoma cell line syndecan-4 was downregulated (90). The gene discussed is SDC4; the disease is mesothelioma.