The proinflammatory NF-κB, which is a commonly overactive gene in colon cancer, participates in the control of transcription of more than 3,000 target genes, including NOS2, cyclooxygenase 2 (COX-2, also called PTGS2), NOX1, NOX4, NOX2, interleukins, AKT1, TNF, EGFR, GADD45B, MAP2K6 (MEK6), NQO1, STAT3, TP53, BCL2A1, BCL-X, p21CIP1/WAF1, BIRC2, GADD45B, NQO1, PDGFB, PLAU, SOD2, REL, and MYC. This evidence concerns the gene MAP2K6 and malignant colon neoplasm.