Proteomic analysis of melanoma metastases in comparison to primary tumors has shown upregulation of several proteins, implicated as metastasis-related proteins, such as lactate dehydrogenase, heat shock protein 90 KDa, glucose transporter 1, Macrophage migration inhibitory factor, Protein DJ-1, pyruvate kinase isozyme 2 and prohibitin-2 [102]. Here, PHB2 is linked to melanoma.