Examining the over-expressed genes in AML across the top 15 subnetworks (Table S4 in Supporting Document S1), COSSY identified LYN/PI3K/AKT signaling (LYN, PIK3R2, AKT1), lysosome complex (LAMP2, CTSD, ATP6AP1), and integrin signaling pathways (ITGAX, ITGB2, FCER1G) as key pathways in driving this disease. The gene discussed is CTSD; the disease is acute myeloid leukemia.