Examining the over-expressed genes in AML across the top 15 subnetworks (Table S4 in Supporting Document S1), COSSY identified LYN/PI3K/AKT signaling (LYN, PIK3R2, AKT1), lysosome complex (LAMP2, CTSD, ATP6AP1), and integrin signaling pathways (ITGAX, ITGB2, FCER1G) as key pathways in driving this disease. This evidence concerns the gene ITGB2 and acute myeloid leukemia.