PIK3R2 and acute myeloid leukemia: Examining the over-expressed genes in AML across the top 15 subnetworks (Table S4 in Supporting Document S1), COSSY identified LYN/PI3K/AKT signaling (LYN, PIK3R2, AKT1), lysosome complex (LAMP2, CTSD, ATP6AP1), and integrin signaling pathways (ITGAX, ITGB2, FCER1G) as key pathways in driving this disease.