Furthermore, we analyse the functional impact of Syndecan-1 depletion on the expression of effectors of the stemness-related IL-6/JAK2/STAT3 and Wnt signaling pathways, its developmental plasticity based on epithelial and mesenchymal marker expression and cell morphology, and its influence on the sphere and cyst formation capability in suspension culture. This evidence concerns the gene SDC1 and cyst.