In addition, our data showed that the HCC tissues showing high expression of both GRB2 and GAB1 also displayed the activation of ERK1 protein, suggesting that GRB2 and GAB1 might induce the activation of the HGF/MAPK/ERK pathway, which has been tied to oncogenic transformation and cancer progression in HCC [49,50]. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.