Furthermore, using eukaryotic expression of DKK1 shRNA, we showed that knockdown of DKK1 suppresses the migration and invasion of NSCLC cell line LTEP-a-2.The results indicate that DKK1 might have a positive role in the progression of NSCLC, but the mechanism involved in invasion needs further studying. This evidence concerns the gene DKK1 and non-small cell lung carcinoma.