Overexpression of GATA-4 or GATA-6 in the heart, as these mice age out past 6 months, each appears to program a similar extent of maladaptive cardiac hypertrophy, while cardiac-specific deletion of either Gata4 or Gata6 from the heart appears to render the heart less adapted and more prone to failure, hence both genes appear to also be necessary for optimal cardiac “health” and physiology [4], [6], [11]. The gene discussed is GATA4; the disease is cardiac hypertrophy.