However, only the GATA-6 transgene restored the ability of Gata6 cardiac-specific deleted mice to compensate and resist heart failure after TAC stimulation, as the GATA-4 transgene replacement in the Gata6 null background produced even slightly worse cardiac function after TAC (Fig. 2D), although left ventricular end diastolic dimension and septal thicknesses were not significantly changed (Fig. 2E and F). This evidence concerns the gene GATA4 and heart failure.