GATA4 and cardiac hypertrophy: While both GATA-4 and GATA-6 overexpression in the heart, as driven by the αMHC promoter, can lead to mild cardiac hypertrophy by 6–8 months of age [4], [6], [11], mice containing both the GATA-4 and GATA-6 transgene did not show induction of hypertrophy at 8 weeks of age (Fig. 1C, and data not shown).