We found two major types of complexes that are affected by miRNAs during cancer progression; the first contains SMAD3, SMAD2, SMAD4, SMAD6, FOXO1, HOXC8, and SKIL, which are connected to AKT1, which is in turn a key modulator of TGF-B signaling pathway [40]. This evidence concerns the gene SMAD2 and cancer.