The goals of the present study were (i) to determine the frequency and spectrum of variants in the PPARD gene in four different cohorts of CRC patients including 303 tissue samples from CRC, and 150 blood samples from: 50 sporadic CRC patients, 50 patients with 2 affected first-degree relatives, and 50 hereditary patients with ≥3 affected first-degree relatives, and (ii) to evaluate potential relationship of variants with clinicopathological variables. Here, PPARD is linked to colorectal carcinoma.