As a consequence of IL-10 signalling, the expression of SOCS3 was highly upregulated in the SLE patients (FC 4.2 in the CD4+ T cells, FC 4.7 in the CD16− monocytes and FC 17.1 in the CD16+ monocytes) (Table S4). Here, SOCS3 is linked to systemic lupus erythematosus.