TNFRSF9 and neoplasm: Fig. 5B shows the production profiles of the Ag-specific IgG isotypes. Tumor-bearing animals treated with pE7+pIL-2+anti-4-1BB Abs also had significantly lower production of Ag-specific IgG2b isotypes compared to animals treated with either pE7+pIL-2+control Abs or pE7 alone. The ratios of IgG2b to IgG1 were 2.8 for pE7+pcDNA3, 4.9 for pE7+pIL-2+control Abs, and 2.2 for pE7+pIL-2+anti-4-1BB Abs (Fig. 5C).