In terms of memory responses, concurrent treatment with E7 DNA vaccines+IL-2 cDNA+anti-4-1BB Abs showed a higher induction of memory CD8+ T cell phenotypes (CD44highCD8+ T cells) and protective antitumor responses to parental tumor cell re-challenge, as well as increased IFN-γ memory responses to a tumor antigen. This evidence concerns the gene TNFRSF9 and neoplasm.