To test whether the combined administration of E7 DNA vaccines (pE7) with either IL-2 or IL-15 cDNA induces greater antitumor therapeutic activity than pE7 alone, we injected tumor (5 mm)-bearing animals with 50 μg of pE7 with either 10 μg of IL-2 (pIL-2) or IL-15 (pIL-15) cDNA at 0, 4 and 11 days and checked tumor growth patterns over the time points following treatment. Here, IL15 is linked to neoplasm.