CFH and age-related macular degeneration: Logistic regression analysis stratified by Y402H genotype showed a highly significant 12-fold reduction in AMD progression in the group assigned to simvastatin if they were homozygous for the at risk C allele at Y402H of the CFH gene [OR = 0.08 (95%CI 0.02, 0.45), p = 0.004], but not in the combined group of CT and TT genotypes (p = 0.74) (Table 5).