CASP3 and hepatocellular carcinoma: Our data also demonstrate that the high Ad-G-AT2R-EGFP dose –induced AT2R overexpression in all the HCC cell lines tested produced apoptosis (Fig. 4) involving cell death signaling pathway that is dependent on activation of p38 MAPK, pJNK, and caspase-3 and inactivation of pp42/44 MAPK (Erk1/2) (Fig. 5 and Fig. 6).