It is interesting to note that HL-60/ADM cells displayed an evident lower mitochondrial ATPase activity(38.2±2.0 U) than HL-60 cells (132.1±14.7 U), which indicated that down-regulated expression of mitochondrial ATPsyn-β and decreased ATPase activity in HL-60/ADM cells were both associated with drug resistance of leukemia cells. Here, DNAH8 is linked to leukemia.