In this study, higher concentrations of MBL inhibited C. albicans-induced secretion of such proinflammatory cytokines and chemokines as TNF-α and IL-8, indicating that MBL might be implicated in the anti-inflammatory effect and immunoregulation, reducing the incidence of shock and prevent endotoxemia-induced death. The gene discussed is TNF; the disease is serum lipopolysaccharide activity.