Among those subjects with HIV, TB co-infection (either active TB or LTBI) did not further lower CD161++CD8+ T cell population compared to those with HIV mono-infection (median = 0.75%, range = 0.07–6.3; p = 0.97 and median = 1.22%, range = 0.095–3.63; p = 0.35 respectively, Fig. 2B). This evidence concerns the gene KLRB1 and infection.