COMT and cancer: We found that 69 (51.8%) of the 133 differentially expressed proteins mapped within the 25 identified RARs, and a number of them (AKR1B10, AKR7A2, ENO1, EPHX2, ADH1, ADH1C, ADH1A, ADH6, GSTA1, APOE, HSP90AA1, GNMT, COMT, HIST1H2AA, HIST1H1B , ARG1, ect ) are cancer-related genes (Table 1 and Table S3).