Genes involved in these functionalities and highly expressed in our human and mouse CPE datasets were, for example, ANXA5, −6, ATOX1, CFH, CD9, CD24, CD63, CDH11, HLA-B, HIST1H1C, HSPA5, HYAL, IGF2, IGF1R, IGFBP2, −5, −7, and ITGAV. Indeed, according to the literature, the CPE is an important importer of T-cells and virus particles into the CNS [51]–[53] and is involved in autoimmune inflammation in multiple sclerosis [21]. Here, IGF2 is linked to multiple sclerosis.